Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Abstract Substance Use Disorder (SUD) is one of the major mental illnesses that is
terrifically intensifying worldwide. It is becoming overwhelming due to limited options for …

Importance There are no medications approved by authorities for the treatment of
amphetamine or methamphetamine dependence, and studies investigating the …

Background Cocaine use contines to be a significant public health problem world‐wide.
However, despite substantial research efforts, no pharmacotherapies are approved for the …

Introduction The COVID-19 pandemic was preceded by an ongoing overdose crisis and
linked to escalating drug overdose deaths in British Columbia (BC). At the outset of these …

Abstract Background and Aims There is currently no standard of care for pharmacological
treatment of amphetamine‐type stimulant (ATS) use disorder (ATSUD). This systematic …

Drug addiction is responsible for millions of deaths per year around the world. Still, its
management as a chronic disease is shadowed by misconceptions from the general public …

• People who use drugs have an increased risk of death owing to the toxic, unregulated drug
supply.• Providing a safe supply of substances, including opioids such as hydromorphone …

Background: Preliminary evidence suggest clozapine is associated with more favorable
impact on concurrent substance use disorder related outcomes in patients with concurrent …

Importance Studies have suggested a rise in opioid-and stimulant-involved overdoses in
recent years in North America. This risk may be acute for individuals who have had contact …