The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin,
SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved …

Alzheimer's disease, a highly prevalent form of dementia, targets neuron function beginning
from the hippocampal region and expanding outwards. Alzheimer's disease is caused by …

A cohort of morphologically heterogenous doublecortin immunoreactive (DCX+)“immature
neurons” has been identified in the cerebral cortex largely around layer II and the amygdala …

The amyloid precursor protein (APP), one key player in Alzheimer's disease (AD), is
extensively processed by different proteases. This leads to the generation of diverging …

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions
including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and …

FAM20C is a gene coding for a protein kinase that targets SXE/pS motifs on different
phosphoproteins belonging to diverse tissues. Pathogenic variants of FAM20C are …

Background: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease
with poor clinical outcome. Nucleotide binding and oligomerization domain-like receptor …

Neurotensin receptor-3 or sortilin is a vacuolar protein sorting 10 protein domain (Vps10p)
has been firstly discovered in the human brain, it acts as receptor or co-receptor of the cell …

Shank3 is a postsynaptic scaffolding protein of excitatory synapses. Mutations or variations
of SHANK3 are associated with various psychiatric and neurological disorders. We set to …

The accumulation of excess intracellular or extracellular amyloid beta (Aβ) is one of the key
pathological events in Alzheimer's disease (AD). Aβ is generated from the cleavage of …