Many exogenous sources of stress can lead to cell death. In recent years, endogenous
cellular sources of stress have also been identified, including the stress that arises from the …

Pancreatic cancer is one of the most lethal of human malignancies ranking 4th among
cancer-related death in the western world and in the United States, and potent therapeutic …

Using genome-wide approaches, we have elucidated the regulatory circuitry governed by
the XBP1 transcription factor, a key effector of the mammalian unfolded protein response …

Continuous regeneration of digestive enzyme (zymogen)-secreting chief cells is a normal
aspect of stomach function that is disrupted in precancerous lesions (eg metaplasias …

Humoral immunity is characterized by the generation of Ab-secreting plasma cells and
memory B cells that can more rapidly generate specific Abs upon Ag exposure than their …

BACKGROUND & AIMS: Invasive pancreatic ductal adenocarcinoma is thought to originate
from duct-like lesions called pancreatic intraepithelial neoplasia (PanIN). PanINs progress …

Despite the prevalence of oncogenic Kras mutations in the earliest stages of pancreatic
ductal adenocarcinoma, the cellular compartment in which oncogenic Kras initiates …

It has long been known that differentiated cells can switch fates, especially in vitro, but only
recently has there been a critical mass of publications describing the mechanisms adult …

We hypothesized that basic helix–loop–helix (bHLH) MIST1 (BHLHA15) is a “scaling factor”
that universally establishes secretory morphology in cells that perform regulated secretion …

Differentiated cells across multiple species and organs can re‐enter the cell cycle to aid in
injury‐induced tissue regeneration by a cellular program called paligenosis. Here, we show …