Diabetes mellitus-related cardiomyopathy (DMCMP) was originally described as a dilated
phenotype with eccentric left ventricular (LV) remodelling and systolic LV dysfunction …

The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

OBJECTIVE—The etiology of type 2 diabetes often involves diet-induced obesity (DIO),
which is associated with elevated plasma fatty acids and lipoprotein associated triglycerides …

Adenylate kinase and downstream AMP signaling is an integrated metabolic monitoring
system which reads the cellular energy state in order to tune and report signals to metabolic …

Obesity results in marked alterations in cardiac energy metabolism, with a prominent effect
being an increase in fatty acid uptake and oxidation by the heart. Obesity also results in …

Malonyl-CoA can be formed within the mitochondria, peroxisomes, and cytosol of
mammalian cells. Besides being an intermediate in the pathways of de novo fatty acid …

The main role of insulin in the heart under physiological conditions is obviously the
regulation of substrate utilization. Indeed, insulin promotes glucose uptake and its utilization …

Heart disease is the leading cause of death in patients with diabetes. 1 Although advances
in medical management and lifestyle interventions have reduced cardiovascular mortality in …