The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …

Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic
waves that generate the differentiated blood cells required for embryonic development while …

In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …

During embryogenesis, waves of hematopoietic progenitors develop from hemogenic
endothelium (HE) prior to the emergence of self-renewing hematopoietic stem cells (HSCs) …

Tissue-resident macrophages play essential functions in the maintenance of tissue
homeostasis and repair. Recently, the endocardium has been reported as a de novo …

Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …

During osteoclast differentiation, the expression of the transcription factor nuclear factor of
activated T cell 1 (Nfatc1) increases in an autoproliferative manner. Nfatc1 isoforms are of …

Hematopoietic stem cells (HSCs) generated during embryonic development are able to
maintain hematopoiesis for the lifetime, producing all mature blood lineages. HSC …

The hierarchical framework of the adult blood system as we know it from current medical and
hematology textbooks, displays a linear branching network of dividing and differentiated …