Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Biocatalysis harnesses enzymes to make valuable products. This green technology is used
in countless applications from bench scale to industrial production and allows practitioners …

Over the past 16 years, genetic code expansion and reprogramming in living organisms has
been transformed by advances that leverage the unique properties of pyrrolysyl-tRNA …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

Directed enzyme evolution has revolutionized the rapid development of enzymes with
desired properties. However, the lack of a high-throughput method to identify the most …

Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Directed evolution has become one of the most successful and powerful tools for protein
engineering. However, the efforts required for designing, constructing, and screening a large …

Directed evolution is one of the most powerful tools for protein engineering and functions by
harnessing natural evolution, but on a shorter timescale. It enables the rapid selection of …

Cannabinoids are important therapeutical molecules for human ailments, cancer treatment,
and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from …

Synthetic biology aims at designing new biological functions from first principles. These new
designs allow to expand the natural solution space and overcome the limitations of naturally …