Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection

E Witte, K Witte, K Warszawska, R Sabat… - Cytokine & growth factor …, 2010 - Elsevier
Interleukin (IL)-22 is a member of the IL-10 cytokine family that is produced by special
immune cell populations, including Th22, Th1, and Th17 cells, classical and non-classical …

TH17 and TH22 cells: a confusion of antimicrobial response with tissue inflammation versus protection

M Akdis, O Palomares, W van de Veen… - Journal of Allergy and …, 2012 - Elsevier
Substantial progress in understanding mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumors, organ transplantation, chronic infections, and pregnancy is in …

Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases

M Akdis, S Burgler, R Crameri, T Eiwegger… - Journal of allergy and …, 2011 - Elsevier
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

A double edged sword role of interleukin-22 in wound healing and tissue regeneration

T Arshad, F Mansur, R Palek, S Manzoor… - Frontiers in …, 2020 - frontiersin.org
Wound healing and tissue regeneration is an intricate biological process that involves repair
of cellular damage and maintenance of tissue integrity. Cascades involved in wound healing …

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

SY Pu, F Xiao, S Schor, E Bekerman, F Zanini… - Antiviral research, 2018 - Elsevier
There is an urgent need for strategies to combat dengue virus (DENV) infection; a major
global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular …

Natural killer cells and hepatitis C: action and reaction

K Cheent, SI Khakoo - Gut, 2011 - gut.bmj.com
In 1989, hepatitis C virus (HCV) was first identified as the infectious agent responsible for
human non-A, non-B hepatitis. Two decades later, HCV remains a global public health …

[HTML][HTML] Protective and pathological properties of IL-22 in liver disease: implications for viral hepatitis

MA Cobleigh, MD Robek - The American journal of pathology, 2013 - Elsevier
Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection affect> 500 million
people worldwide and are significant causes of liver cirrhosis and hepatocellular carcinoma …

Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV

MA Stacey, M Marsden, S Clare, G Dolton, G Stack… - Cell host & …, 2014 - cell.com
During primary infection, murine cytomegalovirus (MCMV) spreads systemically, resulting in
virus replication and pathology in multiple organs. This disseminated infection is ultimately …

The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies

J Lücke, M Sabihi, T Zhang, LF Bauditz… - Seminars in …, 2021 - Springer
The human liver fulfills several vital tasks daily and possesses an impressive ability to self-
regenerate. However, the capacity of this self-healing process can be exhausted by a variety …

Genes and hepatitis C: susceptibility, fibrosis progression and response to treatment

M Romero‐Gomez, M Eslam, A Ruiz… - Liver …, 2011 - Wiley Online Library
Hepatitis C virus contact and infection show three different phenotypes: spontaneous viral
clearance (SVC), chronic hepatitis C (CHC) and sustained virological response (SVR) …