Computational oncology is a generic term that encompasses any form of computer-based
modelling relating to tumour biology and cancer therapy. Mathematical modelling can be …

Despite advances in biomedical research that have deepened our understanding of cancer
hallmarks, resulting in the discovery and development of targeted therapies, the success …

Purpose Neutropenia is a severe adverse-event of chemotherapeutics. Neutrophils (ANC)
are mainly regulated by granulocyte colony stimulating factor (G-CSF). The aim was to …

Neutropenia is a serious toxic complication of chemotherapeutic treatment. For years,
mathematical models have been developed to better predict hematological outcomes during …

Significant scientific advances in biomedical research have expanded our knowledge of the
molecular basis of carcinogenesis, mechanisms of cancer growth, and the importance of the …

Non-small cell lung cancer is often diagnosed at advanced stages, and many patients are
still treated with classical chemotherapy. The unselective nature of chemotherapy often …

Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2-advanced or metastatic
breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim …

Aim The objective of the present study was to use pharmacokinetic–pharmacodynamic
modelling to characterize the effects of chemotherapy on the granulopoietic system and to …

High‐dose melphalan (HDM) is part of the conditioning regimen in patients with multiple
myeloma (MM) receiving autologous stem cell transplantation (ASCT). However, individual …

Neutropenia is one of the most common dose-limiting toxocities associated with anticancer
drug therapy. The ability to predict the probability and severity of neutropenia based on in …