[HTML][HTML] Insulin-like growth factor 1 (IGF-1) signaling in glucose metabolism in colorectal cancer

A Kasprzak - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is one of the most common aggressive carcinoma types worldwide,
characterized by unfavorable curative effect and poor prognosis. Epidemiological data re …

[HTML][HTML] Emerging role of the pentose phosphate pathway in hepatocellular carcinoma

MA Kowalik, A Columbano, A Perra - Frontiers in oncology, 2017 - frontiersin.org
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it
has been noticed that malignant transformation and metabolic reprogramming are closely …

[HTML][HTML] TCA cycle rewiring as emerging metabolic signature of hepatocellular carcinoma

S Todisco, P Convertini, V Iacobazzi, V Infantino - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is a common malignancy. Despite progress in treatment,
HCC is still one of the most lethal cancers. Therefore, deepening molecular mechanisms …

[HTML][HTML] Molecular targets and signaling pathways of microRNA-122 in hepatocellular carcinoma

KH Chun - Pharmaceutics, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading global causes of cancer mortality.
MicroRNAs (miRNAs) are small interfering RNAs that alleviate the levels of protein …

[HTML][HTML] A modified protocol of diethylnitrosamine administration in mice to model hepatocellular carcinoma

A Memon, Y Pyao, Y Jung, JI Lee, WK Lee - International journal of …, 2020 - mdpi.com
We aimed to create an animal model for hepatocellular carcinoma (HCC) with a short time, a
high survival rate, as well as a high incidence of HCC in both males and females than …

Curcumin Attenuates N-Nitrosodiethylamine-Induced Liver Injury in Mice by Utilizing the Method of Metabonomics

P Qiu, J Sun, S Man, H Yang, L Ma, P Yu… - Journal of agricultural …, 2017 - ACS Publications
N-Nitrosodiethylamine (DEN) exists as a food additive in cheddar cheese, processed meats,
beer, water, and so forth. It is a potent hepatocarcinogen in animals and humans. Curcumin …

Unraveling the Sweet Secrets of HCC: Glucometabolic Rewiring in Hepatocellular Carcinoma

SA Bhat, Z Farooq, H Ismail… - … in Cancer Research …, 2023 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is the primary form of liver cancer. It causes∼ 800 000
deaths per year, which is expected to increase due to increasing rates of obesity and …

[HTML][HTML] IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma

C Zhao, Q Wang, B Wang, Q Sun, Z He, J Hong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
It has been reported that the epithelial-mesenchymal transition (EMT) plays an important
role in hepatocellular carcinoma (HCC). However, the relationship between the insulin-like …

Cancer cell metabolism as new targets for novel designed therapies

IM de Mas, E Aguilar, A Jayaraman… - Future medicinal …, 2014 - Taylor & Francis
Metabolic processes are altered in cancer cells, which obtain advantages from this
metabolic reprogramming in terms of energy production and synthesis of biomolecules that …

[HTML][HTML] Gene network analysis reveals a novel 22-gene signature of carbon metabolism in hepatocellular carcinoma

J Zhang, M Baddoo, C Han, MJ Strong, J Cvitanovic… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Although much progress has been made in understanding cancer cellular metabolism
adaptation, the co-regulations between genes of metabolism and cancer pathways and their …