Recent advances in drug polymorphs: Aspects of pharmaceutical properties and selective crystallization

Q Shi, H Chen, Y Wang, J Xu, Z Liu, C Zhang - International journal of …, 2022 - Elsevier
Drug polymorphism, an established term used to describe the phenomenon that a drug can
exist in different crystalline phases, has attracted great interests in pharmaceutical field in …

Recent Advances in Nanomechanical Measurements and Their Application for Pharmaceutical Crystals

MK Mishra, P Mahur, P Manimunda… - Molecular …, 2023 - ACS Publications
Mechanical behavior of pharmaceutical crystals directly impacts the formulation
development and manufacturing of drug products. The understanding of crystal structure …

Bendable and twistable crystals of flufenamic acid form III with bending mechanofluorochromism behavior

Y Liu, P Yang, K Zhang, J Xu, S Wu… - Crystal Growth & …, 2022 - ACS Publications
Mechanical flexible organic crystals with optical properties have attracted increasing
research interest, because of their unusual phenomena and broad application prospects …

Structural basis for mechanical anisotropy in polymorphs of a caffeine–glutaric acid cocrystal

MK Mishra, K Mishra, A Narayan, CM Reddy… - Crystal Growth & …, 2020 - ACS Publications
Insights into structure–mechanical property correlations in molecular and multicomponent
crystals have recently attracted significant attention owing to their practical applications in …

Structure-mechanics and improved tableting performance of the drug-drug cocrystal metformin: salicylic acid

JA Bhatt, D Bahl, K Morris, LL Stevens… - European Journal of …, 2020 - Elsevier
Drug-drug cocrystals (DDC) represent a unique subset of pharmaceutical materials offering
distinct advantages in combination therapies, pharmacokinetics, and patient compliance …

Tablet capping predictions of model materials using multivariate approach

P Basim, RV Haware, RH Dave - International journal of pharmaceutics, 2019 - Elsevier
The present study demonstrated the prediction of predominant root causes of capping
behavior as a function of the powder rheological and the mechanical behavior of …

Multivariate Analysis of a Highly Effective Drug Combination Tablet Containing the Antiepileptic Drug Gabapentin to Enhance Pharmaceutical Properties with a …

C Zhao, X Su, L Fang, Z Shang, Z Li… - Crystal Growth & …, 2022 - ACS Publications
A thorough grasp of the relationship between the crystal structure and properties is
necessary for the design of crystals with specific properties using crystal engineering …

An update on solid-state form, crystal modification and transition issues related to tablet manufacturing

S Zhou, T Yang, C Qian, F Wu, Y Hong, X Lin - Journal of Drug Delivery …, 2024 - Elsevier
Improving the tableting-related properties (flowability, compressibility, compactibility, etc.) of
pharmaceutical materials, especially active pharmaceutical ingredients (APIs), is critical for …

Mechanical anisotropy and tabletability of famotidine polymorphs

PP Upadhyay, MK Mishra, U Ramamurty, AD Bond - CrystEngComm, 2022 - pubs.rsc.org
In the drug development process, early characterization of solid forms can help to envisage
the bulk processability of a powder, which should assist in selecting an optimal solid form. In …

General Commentary: A Tribute to Professor Kenneth R. Morris–Scientist, Teacher, Mentor, Friend… and Underappreciated Academic Arborist

PLD Wildfong - Pharmaceutical Research, 2023 - Springer
This special issue of Pharmaceutical Research is dedicated to Professor Kenneth R. Morris,
who for more than 3 decades has been a leader in research devoted to the interplay …