Several macromolecular machines collaborate to produce eukaryotic messenger RNA. RNA
polymerase II (Pol II) translocates along genes that are up to millions of base pairs in length …

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …

The programmes that direct an organism's development and maintenance are encoded in its
genome. Decoding of this information begins with regulated transcription of genomic DNA …

RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …

We present RADAR—a rigorously annotated database of A-to-I RNA editing (available at
http://RNAedit. com). The identification of A-to-I RNA editing sites has been dramatically …

Codon optimization describes gene engineering approaches that use synonymous codon
changes to increase protein production. Applications for codon optimization include …

Adenine to Inosine RNA editing is a widespread co-and post-transcriptional mechanism
mediated by ADAR enzymes acting on double stranded RNA. It has a plethora of biological …

RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods
for identifying in vivo targets of an RBP are imperfect and not amenable to examining small …

A substantial fraction of the metazoan transcriptome undergoes circadian oscillations in
many cells and tissues. Based on the transcription feedback loops important for circadian …