The importance of leptin to reproduction

GV Childs, AK Odle, MC MacNicol… - Endocrinology, 2021 - academic.oup.com
A healthy nutritional state is required for all aspects of reproduction and is signaled by the
adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little …

Leptin and the regulation of body weight in mammals

JM Friedman, JL Halaas - Nature, 1998 - nature.com
The assimilation, storage and use of energy from nutrients constitute a homeostatic system
that is essential for life. In vertebrates, the ability to store sufficient quantities of energy-dense …

Leptin signaling and leptin resistance

Y Zhou, L Rui - Frontiers of medicine, 2013 - Springer
Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

Leptin: a review of its peripheral actions and interactions

S Margetic, C Gazzola, GG Pegg, RA Hill - International journal of …, 2002 - nature.com
Following the discovery of leptin in 1994, the scientific and clinical communities have held
great hope that manipulation of the leptin axis may lead to the successful treatment of …

Mechanisms of leptin action and leptin resistance

MG Myers, MA Cowley, H Münzberg - Annu. Rev. Physiol., 2008 - annualreviews.org
The adipose tissue–derived hormone leptin acts via its receptor (LRb) in the brain to
regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a …

The leptin receptor

LA Tartaglia - Journal of Biological Chemistry, 1997 - ASBMB
Of the many genetic obesity syndromes, none have been as intensively studied as ob/ob
and db/db mice. These two mutant mice were originally identified over 30 years ago (1, 2) …

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

SH Bates, WH Stearns, TA Dundon, M Schubert… - Nature, 2003 - nature.com
Secretion of leptin from adipocytes communicates body energy status to the brain by
activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and …

Intracellular signalling pathways activated by leptin

G Frühbeck - Biochemical Journal, 2006 - portlandpress.com
Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of
members of the long-chain helical cytokine family. It is mainly produced by adipocytes in …

Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance

M Schneeberger, R Gomis… - Journal of endocrinology, 2014 - joe.bioscientifica.com
In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

The biology of leptin: a review

KL Houseknecht, CA Baile, RL Matteri… - Journal of animal …, 1998 - academic.oup.com
Leptin, a 16-kDa protein secreted from white adipocytes, has been implicated in the
regulation of food intake, energy expenditure, and whole-body energy balance in rodents …