Microtubules are critical for a variety of important functions in eukaryotic cells. During
intracellular trafficking, molecular motor proteins of the kinesin superfamily drive the …

Abstract γ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After
nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins …

A fair amount of research on microtubules since their discovery in 1963 has focused on their
dynamic tips. In contrast, the microtubule lattice was long believed to be highly regular and …

Microtubules are dynamic cytoskeletal polymers, and their organization and stability are
tightly regulated by numerous cellular factors. While regulatory proteins controlling the …

The γ-tubulin ring complex (γ-TuRC) has essential roles in centrosomal and non-
centrosomal microtubule organization during vertebrate mitosis. While there have been …

During cell division, chromosome segregation is orchestrated by a microtubule-based
spindle. Interaction between spindle microtubules and kinetochores is central to the bi …

Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice.
We show here that taxol has different effects on different single-isotype microtubule lattices …

Microtubules are tubes of about 25 nm in diameter that are critically involved in a variety of
cellular functions, including motility, compartmentalization, and division. They are …

Microtubules are essential cytoskeletal polymers that exhibit stochastic switches between
tubulin assembly and disassembly. Here, we examine possible mechanisms for these …

CAMSAPs are proteins that show microtubule minus-end–specific localization, decoration,
and stabilization. Although the mechanism for minus-end recognition via their C-terminal …