Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review

S Yang, J Zhao, X Sun - Drug design, development and therapy, 2016 - Taylor & Francis
As a progressive chronic disease, age-related macular degeneration (AMD) is the leading
cause of irreversible vision impairment worldwide. Experimental and clinical evidence has …

Defining response to anti-VEGF therapies in neovascular AMD

WM Amoaku, U Chakravarthy, R Gale, M Gavin… - Eye, 2015 - nature.com
The introduction of anti-vascular endothelial growth factor (anti-VEGF) has made significant
impact on the reduction of the visual loss due to neovascular age-related macular …

Clinical pharmacology of intravitreal anti-VEGF drugs

S Fogli, M Del Re, E Rofi, C Posarelli, M Figus… - Eye, 2018 - nature.com
Clinical efficacy of intravitreal anti-VEGF drugs has been widely demonstrated in several
angiogenesis-driven eye diseases including diabetic macular edema and the neovascular …

[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives

SJ Gasparini, S Llonch, O Borsch, M Ader - Progress in retinal and eye …, 2019 - Elsevier
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …

Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration

JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang… - Cell stem cell, 2017 - cell.com
Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …

[HTML][HTML] Targeting VEGF in eye neovascularization: What's new?: A comprehensive review on current therapies and oligonucleotide-based interventions under …

M Amadio, S Govoni, A Pascale - Pharmacological research, 2016 - Elsevier
Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the
treatment of neovascular AMD and other eye pathologies characterized by ocular …

Real-world experience with brolucizumab in wet age-related macular degeneration: the REBA study

A Bilgic, L Kodjikian, F March de Ribot… - Journal of Clinical …, 2021 - mdpi.com
The aim of the present study was to determine the efficacy and safety of intravitreal
brolucizumab therapy for neovascular age-related macular degeneration (AMD) in the real …

Metabolic dysregulation and neurovascular dysfunction in diabetic retinopathy

T Yumnamcha, M Guerra, LP Singh, AS Ibrahim - Antioxidants, 2020 - mdpi.com
Diabetic retinopathy is a major cause of ocular complications in patients with type 1 and type
2 diabetes in developed countries. Due to the continued increase in the number of people …

Association of baseline characteristics and early vision response with 2-year vision outcomes in the Comparison of AMD Treatments Trials (CATT)

G Ying, MG Maguire, E Daniel, FL Ferris, GJ Jaffe… - Ophthalmology, 2015 - Elsevier
Purpose To evaluate the association of baseline characteristics and early visual acuity (VA)
response with visual outcomes at years 1 or 2 in the Comparison of Age-Related Macular …