Historically, individuals with androgen insensitivity syndrome (AIS) were managed with
removal of gonadal tissue at various ages to avert the risk of gonadal malignancy. Recently …

This paper reviews the current knowledge on the environmental effects on penile
development in humans. The specific focus is on endocrine-disrupting chemicals (EDCs), a …

BACKGROUND Over the past decades, an increasing trend in male external genital
malformations such as cryptorchidism and hypospadias has led to the suspicion that …

Exposure to endocrine‐disrupting chemicals (EDCs) has been suggested to contribute to
the increasing trends of external genital malformation in male newborns. In Northeastern …

Abstract Objective Steroidogenic factor 1 (SF1, NR5A1) is a key transcriptional regulator of
genes involved in the hypothalamic–pituitary–gonadal axis. Recently, SF1 mutations were …

OBJECTIVE: The objective of the study was to evaluate the need of magnetic resonance
imaging and using different approaches (transabdominal, endoluminal and transperineal) in …

This article reviews the literature on intersexuality (disorders of sex development [DSD]) and
transsexuality in Egypt. Egypt's resources for the diagnosis and treatment of rare conditions …

Genetic sex in mammals is determined by the sex chromosomal composition of the zygote.
The X and Y chromosomes are responsible for numerous factors that must work in close …

Einführung Körperliche Geschlechtsentwicklungen, die auf chromosomaler, gonadaler
und/oder anatomischer Ebene untypisch verlaufen, werden als Intergeschlechtlichkeit …

Background Mutations in the HSD17B3 gene are associated with a 46, XY disorder of
sexual development (46, XY DSD) as a result of low testosterone production during …