Seeding is a significant but challenging task for optimizing crystallization process operation,
product quality, and process efficiency. With the development of modern crystallization …

Lithium carbonate is the primary product of the lithium extraction process and is an important
compound for the battery making industry. A major step in the conventional sulfuric acid …

For drug substance manufacturing, it is necessary to have a robust crystallization process
that can isolate quality active pharmaceutical ingredients with the desired crystal size …

Herein, a population balance model (PBM) for a combined cooling and antisolvent
crystallization process for an active pharmaceutical ingredient (API) has been developed …

Islatravir (MK-8591), a highly potent nucleoside reverse transcriptase translocation inhibitor,
is being developed to stem the spread of global HIV infections. Following a nine-enzyme in …

A method to promote aluminum hydroxide crystal growth through pickling Al (OH) 3 as seed
in the ammonia system was proposed to overcome these defects. The experimental results …

With the aim of removing fine particles from a suspension obtained by crystallization, a
selective dissolution process featuring a hydrocyclone is compared against a well …

A case study highlighting the risk of generating undesired hydrate polymorph following
seeded distillative crystallization of an active pharmaceutical ingredient (API) from aqueous …

Active pharmaceutical ingredient (API) particle size distribution is important for both
downstream processing operations and in vivo performance. Crystallization process …

Crystallization is a purification technique applied in a number of industrial fields. In
particular, cooling crystallization is widespread to recover a product in solid form from …