Molecular mechanisms of iron and heme metabolism
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …
Chalcone derivatives: promising starting points for drug design
Medicinal chemists continue to be fascinated by chalcone derivatives because of their
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …
simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a …
Antimalarial drug resistance and novel targets for antimalarial drug discovery
MA Shibeshi, ZD Kifle, SA Atnafie - Infection and drug resistance, 2020 - Taylor & Francis
Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
most prevalent in developing countries. Antimalarial drug resistance is the ability of a …
Microfluidic‐based approaches in targeted cell/particle separation based on physical properties: fundamentals and applications
Cell separation is a key step in many biomedical research areas including biotechnology,
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …
cancer research, regenerative medicine, and drug discovery. While conventional cell sorting …
An overview of drug resistance in protozoal diseases
R Capela, R Moreira, F Lopes - International journal of molecular …, 2019 - mdpi.com
Protozoan diseases continue to be a worldwide social and economic health problem.
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …
Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy
Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell
biology, but study of these organisms using light microscopy is often hindered by their small …
biology, but study of these organisms using light microscopy is often hindered by their small …
COVID-19 Knowledge Graph: a computable, multi-modal, cause-and-effect knowledge model of COVID-19 pathophysiology
The COVID-19 crisis has elicited a global response by the scientific community that has led
to a burst of publications on the pathophysiology of the virus. However, without coordinated …
to a burst of publications on the pathophysiology of the virus. However, without coordinated …
The current understanding and potential therapeutic options to combat COVID-19
The ongoing wreaking global outbreak of the novel human beta coronavirus (CoV)
pathogen was presumed to be from a seafood wholesale market in Wuhan, China, belongs …
pathogen was presumed to be from a seafood wholesale market in Wuhan, China, belongs …
A review of modifications of quinoline antimalarials: mefloquine and (hydroxy) chloroquine
DJ Kucharski, MK Jaszczak, PJ Boratyński - Molecules, 2022 - mdpi.com
Late-stage modification of drug molecules is a fast method to introduce diversity into the
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …
already biologically active scaffold. A notable number of analogs of mefloquine, chloroquine …
Antimalarial quinoline drugs inhibit β-hematin and increase free hemin catalyzing peroxidative reactions and inhibition of cysteine proteases
Malaria caused by Plasmodium affects millions people worldwide. Plasmodium consumes
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …
hemoglobin during its intraerythrocytic stage leaving toxic heme. Parasite detoxifies free …