A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Reactive oxygen species (ROS) are continuously produced as a by-product of mitochondrial
metabolism and eliminated via antioxidant systems. Regulation of mitochondrially produced …

Oxidative stress (OS) has been demonstrated to be involved in the pathogenesis of the two
major types of dementia: Alzheimer's disease (AD) and vascular dementia (VaD). Evidence …

Under physiological conditions, reactive oxygen species (ROS) function as signaling
molecules that control cell function. However in pathological conditions, increased …

The mitochondrial uncoupling protein 2 (UCP2) plays a protective function in the vascular
disease of both animal models and humans. UCP2 downregulation upon high-salt feeding …

Primary open angle glaucoma (POAG) is a multifactorial disease characterized by
progressive retinal ganglion cell death and visual field loss. It is known that alterations in …

Background The amino acid serine is an important substrate for biosynthesis and redox
homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine …

Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. It
uncouples oxygen consumption from ATP synthesis. UCP2 is ubiquitously expressed in …

Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to
the uncoupling protein family and plays an important role in lowering mitochondrial …