Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

The cornea, as a dynamic and responsive tissue, constantly interacts with mechanical forces
in order to maintain its structural integrity, barrier function, transparency and refractive …

Yes-associated protein (YAP) is a key mechanotransduction protein in diverse physiological
and pathological processes; however, a ubiquitous YAP activity regulatory mechanism in …

Animal tissues comprise diverse cell types. However, the mechanisms controlling the
number of each cell type within tissue compartments remain poorly understood. Here, we …

The mechanical cues of the external microenvironment have been recognized as essential
clues driving cell behavior. Although intracellular signals modulating cell fate during sensory …

YAP/TAZ signaling pathway is regulated by a multiplicity of feedback loops, crosstalk with
other pathways, and both mechanical and biochemical stimuli. Computational modeling …

Cancer progression is associated with extensive remodeling of the tumor microenvironment
(TME), resulting in alterations of biochemical and biophysical cues that affect both cancer …

Regulating cell behavior using nanotopography has been widely implemented. To facilitate
cell adhesion, physical nanotopography is usually coated with adhesive proteins such as …

Tissue engineering aims to repair, restore, and/or replace tissues in the human body as an
alternative to grafts and prostheses. Biomaterial scaffolds can be utilized to provide a three …

Proteins control many vital functions in living cells, such as cell growth and cell division.
Reliable coordination of these functions requires the spatial and temporal organization of …