The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Transgenic mice displaying abnormalities in cardiac development and function represent a
powerful new tool for understanding molecular mechanisms underlying normal …

Ceramide is among a number of potential lipotoxic molecules that are thought to modulate
cellular energy metabolism. The heart is one of the tissues thought to become dysfunctional …

Lipoprotein lipase is the principal enzyme that hydrolyzes circulating triglycerides and
liberates free fatty acids that can be used as energy by cardiac muscle. Although lipoprotein …

Anesthetics provide sedation and immobility facilitating echocardiography in mice, but
influence cardiac function. We studied the effects of intraperitoneal and inhaled anesthetic …

The carboxypeptidase ACE2 is a homologue of angiotensin-converting enzyme (ACE). To
clarify the physiological roles of ACE2, we generated mice with targeted disruption of the …

Control db/+ and diabetic db/db mice at 6 and 12 wk of age were subjected to
echocardiography to determine whether contractile function was reduced in vivo and …

A key component of cardiac remodeling after acute myocardial infarction (MI) is the
inflammatory response, which modulates cardiac tissue repair. The purpose of this study …

Background—The neuronal isoform of nitric oxide synthase (nNOS) has been implicated in
the regulation of basal and β-adrenergic inotropy in normal and chronically infarcted hearts …

The receptor for advanced glycation end-products (RAGE) has been implicated in the
pathogenesis of ischemia-reperfusion (I/R) injury in the isolated perfused heart. To test the …