Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1
in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria …

While the cause of autism remains unknown, the high concordance between monozygotic
twins supports a strong genetic component. The importance of genetic factors in autism …

Autism is diagnosed by three major symptom categories: unusual reciprocal social
interactions, impaired communication, and repetitive behaviors with restricted interests …

Deficits in social interaction are important early markers for autism and related
neurodevelopmental disorders with strong genetic components. Standardized behavioral …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse
models with face validity to the core symptoms offer an experimental approach to test …

Mouse models of social dysfunction, designed to investigate the complex genetics of social
behaviors, require an objective methodology for scoring social interactions relevant to …

Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

The importance of genetic factors in autism has prompted the development of mutant mouse
models to advance our understanding of biological mechanisms underlying autistic …

1Departments of Neuroscience and Cell Biology and Pediatrics (Neurology), Robert Wood
Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway …