Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

Z Shi, P Yu, WJ Lin, S Chen, X Hu, S Chen, J Cheng… - Neuron, 2023 - cell.com
The crosstalk between the nervous and immune systems has gained increasing attention for
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …

Pregabalin mitigates microglial activation and neuronal injury by inhibiting HMGB1 signaling pathway in radiation-induced brain injury

Z Zhang, J Jiang, Y He, J Cai, J Xie, M Wu… - Journal of …, 2022 - Springer
Background Radiation-induced brain injury (RIBI) is the most serious complication of
radiotherapy in patients with head and neck tumors, which seriously affects the quality of life …

Blockage of VEGF function by bevacizumab alleviates early-stage cerebrovascular dysfunction and improves cognitive function in a mouse model of Alzheimer's …

M Zhang, Z Zhang, H Li, Y Xia, M Xing, C Xiao… - Translational …, 2024 - Springer
Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant
type of dementia worldwide. It is characterized by the progressive and irreversible decline of …

Activation of LRP1 ameliorates cerebral ischemia/reperfusion injury and cognitive decline by suppressing neuroinflammation and oxidative stress through TXNIP …

CJ Yang, X Li, XQ Feng, Y Chen… - Oxidative Medicine …, 2022 - Wiley Online Library
Cerebral ischemia/reperfusion (I/R) injury is a clinical event associated with high morbidity
and mortality. Neuroinflammation plays a crucial role in the pathogenesis of I/R‐induced …

Mortality of early treatment for radiation-induced brain necrosis in head and neck cancer survivors: a multicentre, retrospective, registry-based cohort study

D Pan, X Rong, D Chen, J Jiang, WT Ng, H Mai… - …, 2022 - thelancet.com
Background The evidence of early treatment for radiation-induced brain necrosis (RN) in
head and neck cancer survivors remains insufficient. This study aimed to determine whether …

Radiation necrosis after radiation therapy treatment of brain metastases: A computational approach

B Ocaña-Tienda, O León-Triana… - PLOS Computational …, 2024 - journals.plos.org
Metastasis is the process through which cancer cells break away from a primary tumor,
travel through the blood or lymph system, and form new tumors in distant tissues. One of the …

Amifostine-Loaded Nanocarrier Traverses the Blood–Brain Barrier and Prevents Radiation-Induced Brain Injury

XH Zhao, JP Cheng, S Gui, M Jiang, D Qi… - … Applied Materials & …, 2023 - ACS Publications
Radiation-induced brain injury (RIBI) is a severe, irreversible, or even life-threatening
cerebral complication of radiotherapy in patients with head and neck tumors, and there is no …

A Synthetic Steroid 5α-Androst-3β, 5, 6β-triol Alleviates Radiation-Induced Brain Injury in Mice via Inhibiting GBP5/NF-κB/NLRP3 Signal Axis

K Zhong, K Liu, Y Song, S Chen, X Hu, R Xue… - Molecular …, 2023 - Springer
Radiotherapy for head and neck tumors can lead to a severe complication known as
radiation-induced brain injury (RIBI). However, the underlying mechanism of RIBI …

Terminally differentiated cytotoxic CD4+ T cells were clonally expanded in the brain lesion of radiation‐induced brain injury

X Ma, Y Zuo, X Hu, S Chen, K Zhong… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Accumulating evidence supports the involvement of adaptive immunity in the
development of radiation‐induced brain injury (RIBI). Our previous work has emphasized …

Mitochondrial-targeting fluorescent small molecule IR-780 alleviates radiation-induced brain injury

C Zhang, J Zheng, W Chen, W Yang, X Tan, X Fan… - Brain Research, 2023 - Elsevier
Radiation-induced brain injury (RIBI) is a common complication of radiation therapy for brain
tumors. Vascular damage is one of the key factors closely related to the severity of the RIBI …