AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …

In the third edition of her popular text, Sex Differences in Cognitive Abilities, Diane Halpern
tackles fundamental questions about the meaning of sex differences in cognition and why …

Objective: To determine the association between age at surgical menopause and both
cognitive decline and Alzheimer disease (AD) pathology in 2 longitudinal cohorts. Methods …

Objective: There is increasing laboratory evidence for a neuroprotective effect of estrogen;
however, the clinical and epidemiologic evidence remains limited and conflicting. We …

The classic view of estrogen actions in the brain was confined to regulation of ovulation and
reproductive behavior in the female of all mamamalian species studied, including humans …

Risk for Alzheimer's disease (AD) is associated with age-related loss of sex steroid
hormones in both women and men. In post-menopausal women, the precipitous depletion of …

Most current Alzheimer's disease (AD) therapies in advanced phases of development target
amyloid β-peptide (Aβ) production, aggregation, or accumulation. Translational models …

Background A statistical model of death due to ovarian cancer, breast cancer, coronary heart
disease, hip fracture, and stroke has suggested that women who undergo prophylactic …

Estrogens have direct effects on the brain areas controlling cognition. One of the most
studied of these regions is the dorsal hippocampal formation, which governs the formation of …