Vaccines and monoclonal antibodies: new tools for malaria control
K Miura, Y Flores-Garcia, CA Long… - Clinical Microbiology …, 2024 - Am Soc Microbiol
Malaria remains one of the biggest health problems in the world. While significant reductions
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend …
Recent advances in the development of adenovirus-vectored vaccines for parasitic infections
Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …
infections, despite the devastating morbidity and widespread effects of parasitic diseases …
Unraveling cell death pathways during malaria infection: what do we know so far?
C Sena-dos-Santos, C Braga-da-Silva, D Marques… - Cells, 2021 - mdpi.com
Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …
of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this …
Antigenic: an improved prediction model of protective antigens
An antigen is a protein capable of triggering an effective immune system response.
Protective antigens are the ones that can invoke specific and enhanced adaptive immune …
Protective antigens are the ones that can invoke specific and enhanced adaptive immune …
The use of transgenic parasites in malaria vaccine research
Introduction: Transgenic malaria parasites expressing foreign genes, for example
fluorescent and luminescent proteins, are used extensively to interrogate parasite biology …
fluorescent and luminescent proteins, are used extensively to interrogate parasite biology …
The case for exploiting cross-species epitopes in malaria vaccine design
CJ Mitran, SK Yanow - Frontiers in Immunology, 2020 - frontiersin.org
The infection dynamics between different species of Plasmodium that infect the same human
host can both suppress and exacerbate disease. This could arise from inter-parasite …
host can both suppress and exacerbate disease. This could arise from inter-parasite …
An in silico analysis of malaria pre-erythrocytic-stage antigens interpreting worldwide genetic data to suggest vaccine candidate variants and epitopes
Failure to account for genetic diversity of antigens during vaccine design may lead to
vaccine escape. To evaluate the vaccine escape potential of antigens used in vaccines …
vaccine escape. To evaluate the vaccine escape potential of antigens used in vaccines …
A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages
C Marin-Mogollon, AM Salman, KMJ Koolen… - Frontiers in Cellular …, 2019 - frontiersin.org
Transgenic malaria parasites expressing fluorescent and bioluminescent proteins are
valuable tools to interrogate malaria-parasite biology and to evaluate drugs and vaccines …
valuable tools to interrogate malaria-parasite biology and to evaluate drugs and vaccines …
Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies
Vaccine-induced sterilizing protection from infection by Plasmodium parasites, the
pathogens that cause malaria, will be essential in the fight against malaria as it would …
pathogens that cause malaria, will be essential in the fight against malaria as it would …
Tissue-specific cellular immune responses to malaria pre-erythrocytic stages
O Silvie, R Amino, JC Hafalla - Current opinion in microbiology, 2017 - Elsevier
Highlights•Protective immunity against malaria can be achieved through immunisation with
live attenuated Plasmodium sporozoites and targets the parasite pre-erythrocytic …
live attenuated Plasmodium sporozoites and targets the parasite pre-erythrocytic …