Iron is a crucial transition metal for virtually all life. Two major destinations of iron within
mammalian cells are the cytosolic iron-storage protein, ferritin, and mitochondria. In …

Iron overload is a risk factor for diabetes. The link between iron and diabetes was first
recognized in pathologic conditions—hereditary hemochromatosis and thalassemia—but …

Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2).
IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs …

Convincing concepts of redox control of gene transcription have been worked out for
prokaryotes and lower eukaryotes, whereas the knowledge on complex mammalian systems …

Introduction Friedreich's ataxia is the most common inherited ataxia. Sources of data
Literature search using PubMed with keywords Friedreich's ataxia together with published …

Objective Friedreich ataxia (FRDA) is an inherited neurodegenerative disease characterized
by ataxia and cardiomyopathy. Homozygous GAA trinucleotide repeat expansions in the first …

Friedreich's Ataxia (FRDA) is an autosomal recessive neurodegenerative disorder, affecting
dorsal root ganglia (DRG), cerebellar dentate nuclei and heart. It is caused by a GAA repeat …

Friedreich ataxia is an inherited neurodegenerative disease caused by frataxin deficiency.
Frataxin is a conserved mitochondrial protein that plays a role in FeS cluster assembly in …

Friedreich's ataxia (FRDA) is a rare early-onset degenerative disease that affects both the
central and peripheral nervous systems, and other extraneural tissues, mainly the heart and …

FeS cluster biogenesis is an essential process in virtually all forms of life. Complex protein
machineries that are conserved from bacteria through higher eukaryotes facilitate assembly …