The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Tissue‐resident memory T cells and lung immunopathology

IS Cheon, YM Son, J Sun - Immunological Reviews, 2023 - Wiley Online Library
Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …

Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes

J Fu, Z Wang, M Martinez, A Obradovic… - Journal of Experimental …, 2023 - rupress.org
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …

Psoriatic and rheumatoid arthritis joints differ in the composition of CD8+ tissue-resident memory T cell subsets

GAM Povoleri, LE Durham, EH Gray, S Lalnunhlimi… - Cell Reports, 2023 - cell.com
Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Delayed antiretroviral therapy in HIV-infected individuals leads to irreversible depletion of skin-and mucosa-resident memory T cells

S Saluzzo, RV Pandey, LM Gail… - Immunity, 2021 - cell.com
People living with HIV (PLWH) are at increased risk for developing skin and mucosal
malignancies despite systemic reconstitution of CD4+ T cells upon antiretroviral therapy …

Human T lymphocytes at tumor sites

S Notarbartolo, S Abrignani - Seminars in Immunopathology, 2022 - Springer
Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …

[HTML][HTML] Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets

PN Shah, GA Romar, A Manukyan, WC Ko… - The Journal of Clinical …, 2024 - jci.org
Delayed-type drug hypersensitivity reactions are major causes of morbidity and mortality.
The origin, phenotype, and function of pathogenic T cells across the spectrum of severity …

Functional heterogeneity of human skin‐resident memory T cells in health and disease

J Strobl, M Haniffa - Immunological Reviews, 2023 - Wiley Online Library
The human skin is populated by a diverse pool of memory T cells, which can act rapidly in
response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have …

[HTML][HTML] Virus-specific TRM cells of both donor and recipient origin reside in human kidney transplants

DM Hullegie-Peelen, HT Mora, DA Hesselink… - JCI insight, 2023 - ncbi.nlm.nih.gov
Tissue-resident lymphocytes (TRLs) are critical for local protection against viral pathogens in
peripheral tissue. However, it is unclear if TRLs perform a similar role in transplanted organs …

[HTML][HTML] Atopic dermatitis pathogenesis: lessons from immunology

LF Santamaria-Babí - Dermatology Practical & Conceptual, 2022 - ncbi.nlm.nih.gov
Translational research has changed the understanding of atopic dermatitis (AD)
pathogenesis beyond the basic mechanisms of immunology. The study in patients of rational …