The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in
regulation of cell survival. In general, moderate levels of ROS/RNS may function as signals …

The state of wound oxygenation is a key determinant of healing outcomes. From a
diagnostic standpoint, measurements of wound oxygenation are commonly used to guide …

Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …

Catalytic anticancer metallodrugs active at low doses could minimize side-effects, introduce
novel mechanisms of action that combat resistance and widen the spectrum of anticancer …

The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …

Glutathione (L-γ-glutamyl-L-cysteinyl-glycine; GSH) in cancer cells is particularly relevant in
the regulation of carcinogenic mechanisms; sensitivity against cytotoxic drugs, ionizing …

The cellular oxidation and reduction (redox) environment is influenced by the production
and removal of reactive oxygen species (ROS). In recent years, several reports support the …

Oxidative stress results from an imbalance of the reactive oxygen species/reactive nitrogen
species (ROS/RNS) production and the oxidants defense system. Extensive research during …