[HTML][HTML] Chemicals inhaled from spray cleaning and disinfection products and their respiratory effects. A comprehensive review

PA Clausen, M Frederiksen, CS Sejbæk… - International journal of …, 2020 - Elsevier
Spray cleaning and disinfection products have been associated with adverse respiratory
effects in professional cleaners and among residents doing domestic cleaning. This review …

[HTML][HTML] Per-and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

JB Sørli, M Låg, L Ekeren, J Perez-Gil, LS Haug… - Toxicology in Vitro, 2020 - Elsevier
The toxicity of some per-and polyfluoroalkyl substances (PFASs), such as perfluorooctane
sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing …

[HTML][HTML] An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

E Da Silva, U Vogel, KS Hougaard, J Pérez-Gil… - Current research in …, 2021 - Elsevier
Inhaled substances, such as consumer products, chemicals at the workplace, and
nanoparticles, can affect the lung function in several ways. In this paper, we explore the …

[HTML][HTML] Bile salt enhancers for inhalation: correlation between in vitro and in vivo lung effects

JB Sørli, KB Sivars, E Da Silva, KS Hougaard… - International Journal of …, 2018 - Elsevier
The lungs have potential as a means of systemic drug delivery of macromolecules. Systemic
delivery requires crossing of the air-blood barrier, however with molecular size-dependent …

[HTML][HTML] Risk assessment of consumer spray products using in vitro lung surfactant function inhibition, exposure modelling and chemical analysis

JB Sørli, S Sengupta, ACØ Jensen, V Nikiforov… - Food and Chemical …, 2022 - Elsevier
Consumer spray products release aerosols that can potentially be inhaled and reach the
deep parts of the lungs. A thin layer of liquid, containing a mixture of proteins and lipids …

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

JB Sørli, Y Huang, E Da Silva… - ALTEX …, 2018 - portal.findresearcher.sdu.dk
Private consumers and professionals may experience acute inhalation toxicity after inhaling
aerosolized impregnation products. The distinction between toxic and non-toxic products is …

[HTML][HTML] Molecular and biophysical basis for the disruption of lung surfactant function by chemicals

E Da Silva, C Autilio, KS Hougaard, A Baun… - … et Biophysica Acta (BBA …, 2021 - Elsevier
With the intention to move away from animal testing for the toxicological evaluation of
chemicals comes the need to develop new approach methodologies which are mechanism …

Acute inhalation toxicity after inhalation of ZnO nanoparticles: lung surfactant function inhibition in vitro correlates with reduced tidal volume in mice

ST Larsen, E Da Silva, JS Hansen… - International …, 2020 - journals.sagepub.com
People can be exposed to zinc oxide (ZnO) by inhalation of consumer products or during
industrial processes. Zinc oxide nanoparticle (NP) exposure can induce acute inhalation …

Plethysmograph training: A refinement for collection of respiration data in mice

JB Sørli, KS Hougaard, N Hadrup - Animal Models and …, 2023 - Wiley Online Library
Inhaled chemicals can harm the airways. Different effects can result in distinct changes in
respiratory patterns; the type of change indicates where and how the respiratory system is …

Experiments and modelling of pulmonary surfactant disruption by aerosolised compounds

H Barlow, SR Sengupta, MT Baltazar… - Colloids and Surfaces B …, 2025 - Elsevier
Within the deep lung, pulmonary surfactant coats the air-liquid interface at the surface of the
alveoli. This complex mixture of amphiphilic molecules and proteins modifies the surface …