Network analysis for a network disorder: the emerging role of graph theory in the study of epilepsy

BC Bernhardt, L Bonilha, DW Gross - Epilepsy & Behavior, 2015 - Elsevier
Recent years have witnessed a paradigm shift in the study and conceptualization of
epilepsy, which is increasingly understood as a network-level disorder. An emblematic case …

Imaging structural and functional brain networks in temporal lobe epilepsy

BC Bernhardt, SJ Hong, A Bernasconi… - Frontiers in human …, 2013 - frontiersin.org
Early imaging studies in temporal lobe epilepsy (TLE) focused on the search for mesial
temporal sclerosis, as its surgical removal results in clinically meaningful improvement in …

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

PE Sanchez, L Zhu, L Verret… - Proceedings of the …, 2012 - National Acad Sciences
In light of the rising prevalence of Alzheimer's disease (AD), new strategies to prevent, halt,
and reverse this condition are needed urgently. Perturbations of brain network activity are …

Deep brain activities can be detected with magnetoencephalography

F Pizzo, N Roehri, S Medina Villalon… - Nature …, 2019 - nature.com
The hippocampus and amygdala are key brain structures of the medial temporal lobe,
involved in cognitive and emotional processes as well as pathological states such as …

Altered functional connectivity and small-world in mesial temporal lobe epilepsy

W Liao, Z Zhang, Z Pan, D Mantini, J Ding, X Duan… - PloS one, 2010 - journals.plos.org
Background The functional architecture of the human brain has been extensively described
in terms of functional connectivity networks, detected from the low–frequency coherent …

Network connectivity in epilepsy: resting state fMRI and EEG–fMRI contributions

M Centeno, DW Carmichael - Frontiers in neurology, 2014 - frontiersin.org
There is a growing body of evidence pointing toward large-scale networks underlying the
core phenomena in epilepsy, from seizure generation to cognitive dysfunction or response …

Interictal epileptiform activity outside the seizure onset zone impacts cognition

H Ung, C Cazares, A Nanivadekar, L Kini, J Wagenaar… - Brain, 2017 - academic.oup.com
Abstract See Kleen and Kirsch (doi: 10.1093/awx178) for a scientific commentary on this
article. Cognitive deficits are common among epilepsy patients. In these patients, interictal …

Altered spontaneous neuronal activity of the default-mode network in mesial temporal lobe epilepsy

Z Zhang, G Lu, Y Zhong, Q Tan, W Liao, Z Wang… - Brain research, 2010 - Elsevier
Increasing evidence from behavioral and neuroimaging studies suggests that mesial
temporal lobe epilepsy (mTLE) is possibly associated with the default-mode brain function …

Resting state networks in temporal lobe epilepsy

M Cataldi, M Avoli, E de Villers‐Sidani - Epilepsia, 2013 - Wiley Online Library
Temporal lobe epilepsy (TLE) is typically described as a neurologic disorder affecting a
cerebral network comprising the hippocampus proper and several anatomically related …

Modelling large motion events in fMRI studies of patients with epilepsy

L Lemieux, A Salek-Haddadi, TE Lund, H Laufs… - Magnetic resonance …, 2007 - Elsevier
EEG-correlated fMRI can provide localisation information on the generators of epileptiform
discharges in patients with focal epilepsy. To increase the technique's clinical potential, it is …