One major role of the eukaryotic peptidic post-translational modifier SUMO in the cell is
transcriptional control. This occurs via modification of virtually all classes of transcriptional …

The androgen receptor (AR) is important in the development of the prostate by regulating
transcription, cellular proliferation, and apoptosis. AR undergoes posttranslational …

The Cancer Genome Atlas (TCGA) projects have advanced our understanding of the driver
mutations, genetic backgrounds, and key pathways activated across cancer types. Analysis …

Background Cells have developed many ways to cope with external stress. One distinctive
feature in acute proteotoxic stresses, such as heat shock (HS), is rapid post-translational …

Prostate cancer (PCa) is the most commonly diagnosed cancer among men in western
countries. Androgen receptor (AR) signaling plays key roles in the development of PCa …

While a protein primary structure is determined by genetic code, its specific functional form is
mostly achieved in a dynamic interplay that includes actions of many enzymes involved in …

In addition to the glucocorticoids, the glucocorticoid receptor (GR) is regulated by post-
translational modifications, including SUMOylation. We have analyzed how SUMOylation …

Endometrial cancer (EC) and ovarian cancer are common gynaecological malignancies.
The impact of androgen action in these cancers is poorly understood; however, there is …

Glucocorticoid receptor (GR) is an essential transcription factor (TF), controlling metabolism,
development and immune responses. SUMOylation regulates chromatin occupancy and …

Androgen receptor (AR) plays an important regulatory role in prostate cancer. AR's
transcriptional activity is regulated by androgenic ligands, but also by post-translational …