Chemical approaches to inhibitors of isoprenoid biosynthesis: targeting farnesyl and geranylgeranyl pyrophosphate synthases
Post-translational lipid modifications farnesylation and geranylgeranylation of proteins
(protein prenylation) have been identified to mediate critical events in cancer, cardiovascular …
(protein prenylation) have been identified to mediate critical events in cancer, cardiovascular …
Recent developments in trans-sialidase inhibitors of Trypanosoma cruzi
M Kashif, A Moreno-Herrera… - Journal of drug …, 2017 - Taylor & Francis
Chagas is a lethal chronic disease that currently affects 8–10 million people worldwide,
primarily in South and Central America. Trypanosoma cruzi trans-sialidase is an enzyme …
primarily in South and Central America. Trypanosoma cruzi trans-sialidase is an enzyme …
In Vitro and In Silico Analysis of New n-Butyl and Isobutyl Quinoxaline-7-carboxylate 1,4-di-N-oxide Derivatives against Trypanosoma cruzi as Trypanothione …
A González-González, O Sánchez-Sánchez… - International Journal of …, 2022 - mdpi.com
American trypanosomiasis is a worldwide health problem that requires attention due to
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …
ineffective treatment options. We evaluated n-butyl and isobutyl quinoxaline-7-carboxylate 1 …
Phenothiazine‐based virtual screening, molecular docking, and molecular dynamics of new trypanothione reductase inhibitors of Trypanosoma cruzi
A González‐González, C Vázquez… - Molecular …, 2023 - Wiley Online Library
Phenothiazine derivatives can unselectively inhibit the trypanothione‐dependent antioxidant
system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine …
system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine …
Macromolecular Targets of Antiparasitic Germacranolide Sesquiterpenoids: An In Silico Investigation
PM Arnston, WN Setzer - Combinatorial Chemistry & High …, 2020 - ingentaconnect.com
Background: The parasitic protozoal infections leishmaniasis, human African
trypanosomiasis, and Chagas disease are neglected tropical diseases that pose serious …
trypanosomiasis, and Chagas disease are neglected tropical diseases that pose serious …
Current discovery progress of some emerging anti-infective chalcones: Highlights from 2016 to 2017
DK Mahapatra, S Ghorai, SK Bharti… - Current Drug …, 2020 - ingentaconnect.com
The anti-infective potentials of the natural products are very well known for centuries and are
a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones …
a part of traditional healing. The foremost therapeutic classes include flavones, isoflavones …
[PDF][PDF] Reposicionamento de Fármacos para a Doença de Chagas
APA Corrêaa, IA Guedesb, LE Dardennec - PIBIC PIBITI - gov.br
O uso do termo" doenças negligenciadas" mostra-se comumente presente em relatos
provenientes de países subdesenvolvidos e em desenvolvimento, referindo-se a quadros …
provenientes de países subdesenvolvidos e em desenvolvimento, referindo-se a quadros …
[HTML][HTML] Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery
JK Petrick - … pyrophosphate synthase of Trypanosoma cruzi by …, 2019 - oak.novartis.com
Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas disease (CD), which mostly
affects underprivileged populations in South and Central America. The current standard of …
affects underprivileged populations in South and Central America. The current standard of …
[PDF][PDF] Synthesis and biological evaluation of novel mononuclear Ru (II) compounds as potential antiviral and cytotoxic agents
SS Anchuri, K Gangarapu, S Thota… - … Research in Applied …, 2016 - lirias.kuleuven.be
Ruthenium (II) complexes of the type [Ru (S) 2 (K)] 2+, where S= 1, 10-phenanthroline and
K= 2-NO2-phenyl thiosemicarbazone (Compound R1) and 2-OH-phenyl thiosemicarbazone …
K= 2-NO2-phenyl thiosemicarbazone (Compound R1) and 2-OH-phenyl thiosemicarbazone …