Bifunctional degrader molecules, also called proteolysis-targeting chimeras (PROTACs), are
a new modality of chemical tools and potential therapeutics to understand and treat human …

FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …

In Alzheimer's disease (AD), the canonical Wnt inhibitor Dickkopf-1 (Dkk1) is induced by β-
amyloid (Aβ) and shifts the balance from canonical towards non-canonical Wnt signalling …

A massive intronic hexanucleotide repeat (GGGGCC) expansion in C9ORF72 is a genetic
origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently …

The ubiquitin-proteasome system is a master regulator of neural development and the
maintenance of brain structure and function. It influences neurogenesis, synaptogenesis …

Neurodevelopmental disorders are highly heterogenous conditions resulting from
abnormalities of brain architecture and/or function. FBXW7 (F-box and WD-repeat-domain …

Targeted protein degradation with proteolysis targeting chimeras (PROTACs) is a powerful
therapeutic modality for eliminating disease-causing proteins through targeted ubiquitination …

Controlled protein degradation is essential for the operation of a variety of cellular processes
including cell division, growth, and differentiation. Identification of the relations between …

Abstract SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular
functions. Typically, substrate phosphorylation is required for SCF recognition and …

The ubiquitin-proteasome system (UPS) mediated protein degradation is crucial to maintain
quantitive and functional homeostasis of diverse proteins. Balanced cellular protein …