Cationic lipids have become known as one of the most versatile tools for the delivery of
DNA, RNA and many other therapeutic molecules, and are especially attractive because …

Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

For cystic fibrosis gene therapy, the aerosolization of genetic materials is the most relevant
delivery strategy to reach the airway epithelium. However, aerosolized formulations have to …

Gene therapy with external gene insertion (eg a suicide gene) and expression specifically in
mutated tumor cells has shown to be a promising strategy in treatment of tumors. However …

Natural lipid molecules are an essential part of life as they constitute the membrane of cells
and organelle. In most of these cases, the hydrophobicity of natural lipids is contributed by …

Twelve new quaternary ammonium sophorolipids with long alkyl chains on the nitrogen
atom were synthesized starting from oleic and petroselinic acid‐based sophorolipids. These …

New synthetic pathways are proposed for the synthesis of a new set of bolaamphiphilic
derivatives starting from microbiologically produced sophorolipids. A total set of 43 new …

In this study, two cationic lipids, each containing an α‐tocopherol moiety and a
biocompatible amino acid headgroup (histidine or lysine) linked through a biodegradable …

Cationic lipids constitute a family of synthetic vectors commonly used for nucleic acids
delivery. We herein report the results of a systematic study that aimed to compare the …