The genetic material of all organisms is susceptible to modification. In some instances, these
changes are programmed, such as the formation of DNA double strand breaks during …

In mammals, most metabolic processes are influenced by biological clocks and feeding
rhythms. The mechanisms that couple metabolism to circadian oscillators are just emerging …

Circadian clocks in peripheral organs are tightly coupled to cellular metabolism and are
readily entrained by feeding-fasting cycles. However, the molecular mechanisms involved …

Abstract Poly (ADP-ribose)(pADPr) is a polymer assembled from the enzymatic
polymerization of the ADP-ribosyl moiety of NAD by poly (ADP-ribose) polymerases …

Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …

The regulation of gene expression requires a wide array of protein factors that can modulate
chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate …

Poly (ADP-ribose) polymerase 1 (PARP1) is an ADP-ribosylating enzyme essential for
initiating various forms of DNA repair. Inhibiting its enzyme activity with small molecules thus …

Poly (ADP-ribosyl) ation, attaching the ADP-ribose polymer chain to the receptor protein, is a
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …

In 1963, Chambon et al. reported the detection of a nicotinamide mononucleotide-activated,
DNA-dependent enzymatic activity in rat liver extracts that catalyzed the synthesis of a …

Cardiovascular complications are considered one of the leading causes of morbidity and
mortality among diabetic patients. Diabetic cardiomyopathy (DCM) is a type of …