Background Breast cancer (BC) is a leading cause of cancer-related death in females
worldwide. Previous studies have demonstrated that matrix metalloproteinases (MMPs) play …

Background Matrix metalloproteinases (MMPs) are regarded to be relevant to the prognosis
of breast cancer. Numerous studies have confirmed the association between MMPs and …

The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal
to cancer deterioration and metastasis. Thus, regulating the TME to improve cancer cell …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous …

Sowing malignant cells (the “seeds” of metastasis) to engraft secondary sites requires a
conducive premetastatic niche (PMN, the “soil” of metastasis). Inflammation and tumor …

Neoplastic growth and dissemination involve increased proteolytic activity that is able to
escape the regulative elements. Matrix metalloproteinases (MMPs), particularly gelatinases …

In transitional cell carcinoma, the most common form of bladder cancer, overexpression of
the matrix metalloproteinases MMP-2 and MMP-9 offers prognostic value as markers of …

Human papillomavirus (HPV) associated cancers, and in particular cervical cancer, are
considered to be directly stimulated by HPV oncogenes. Alternatively, these types of cancers …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that aberrant induction of COX-2 and up-regulation of the prostaglandin cascade …