The lysosome-mediated degradation pathway known as macroautophagy is the most
versatile means through which cells can eliminate and recycle unwanted materials. Through …

Highlights•Subtle changes in axonal transport can modulate protein accumulation at the
synapse.•The huntingtin mutation underlying Huntington's disease disrupts axonal …

Autophagy is a degradative pathway required to maintain homeostasis. Neuronal
autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion …

Neurotransmitters are released at synapses by synaptic vesicles (SVs), which originate from
SV precursors (SVPs) that have traveled along the axon. Because each synapse maintains …

Background Neuroinflammation and oxidative stress plays an important role in the
pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). This study is …

The spatial organization of molecules in a cell is essential for their functions. While current
methods focus on discerning tissue architecture, cell–cell interactions, and spatial …

Rab GTPases are important regulators of intracellular membrane trafficking in eukaryotes.
Both activating and inactivating mutations in Rab genes have been identified and implicated …

Eukaryotic cell compartmentalization relies on long-known membrane-delimited organelles,
as well as on more recently discovered membraneless macromolecular condensates. How …

Huntington's disease (HD) is characterized by protein inclusions and loss of striatal neurons
which result from expanded CAG repeats in the poly-glutamine (polyQ) region of the …

Traumatic injury to the peripheral and central nervous systems very often causes axotomy,
where an axon loses connections with its target resulting in loss of function. The axon …