The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

Human cornea is covered by an aqueous tear film, and the outermost layer of the tear film is
coated by lipids. This so-called tear film lipid layer (TFLL) reduces surface tension of the tear …

Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …

Components of the ocular surface synergistically contribute to maintaining and protecting a
smooth refractive layer to facilitate the optimal transmission of light. At the air–water …

This review critically evaluates a broad range of literature in order to show the relationship
between meibum, tear lipids and the tear film lipid layer (TFLL). The relationship of meibum …

Introduction: The development of ophthalmic formulations able to deliver hydrophilic and
hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has …

Purpose.: To quantify the molecular lipid composition of patient-matched tear and meibum
samples and compare tear and meibum lipid molecular profiles. Methods.: Lipids were …

Lung surfactant and a tear film lipid layer are examples of biologically relevant
macromolecular structures found at the air–water interface. Because of their complexity, they …

Lung surfactant lines the gas-exchange interface in the lungs and reduces the surface
tension, which is necessary for breathing. Lung surfactant consists mainly of lipids with a …

Purpose.: We examined in vitro the potential evaporation-retarding effect of the tear film lipid
layer (TFLL). The artificial TFLL compositions used here were based on the present …