[HTML][HTML] Click chemistry in the synthesis of antibody-drug conjugates
R Dudchak, M Podolak, S Holota… - Bioorganic …, 2024 - Elsevier
Abstract Antibody-Drug Conjugates (ADC) are a new class of anticancer therapeutics with
immense potential. They have been rapidly advancing in the last two decades. This fast …
immense potential. They have been rapidly advancing in the last two decades. This fast …
Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis
The anthraquinone-fused enediynes (AFEs) combine an anthraquinone moiety and a ten-
membered enediyne core capable of generating a cytotoxic diradical species. AFE …
membered enediyne core capable of generating a cytotoxic diradical species. AFE …
DNA Interaction and Cleavage Modes of Anthraquinone-Fused Enediynes: A Study on Tiancimycins, Yangpumicins, and Their Semisynthetic Analogues
Z Wen, Z Zhuang, H Liu, Z Wang, X Feng… - Journal of Medicinal …, 2024 - ACS Publications
Dynemicin A has been the sole prototypical anthraquinone-fused enediyne (AFE) explored
since its discovery in 1989. This study investigates the distinct DNA binding and cleavage …
since its discovery in 1989. This study investigates the distinct DNA binding and cleavage …
Chemical Tagging of N-Alkylamine-Containing Natural Products and Pharmaceuticals through C (sp3)–H Functionalization
C Zhao, Y Wang, A Steele, S Mori, B Shen, M Wasa - 2024 - chemrxiv.org
Development of efficient protocols for introducing handles into natural products and
pharmaceutical agents that are suitable for bioconjugation is a compelling research …
pharmaceutical agents that are suitable for bioconjugation is a compelling research …