Animal models and therapeutic molecular targets of cancer: utility and limitations

M Cekanova, K Rathore - Drug design, development and therapy, 2014 - Taylor & Francis
Cancer is the term used to describe over 100 diseases that share several common
hallmarks. Despite prevention, early detection, and novel therapies, cancer is still the …

[HTML][HTML] Canine mammary tumors as a model for human disease

SM Abdelmegeed, S Mohammed - Oncology letters, 2018 - spandidos-publications.com
Animal models for examining human breast cancer (HBC) carcinogenesis have been
extensively studied and proposed. With the recent advent of immunotherapy, significant …

[HTML][HTML] Epidemiological study of mammary tumors in female dogs diagnosed during the period 2002-2012: a growing animal health problem

Y Salas, A Márquez, D Diaz, L Romero - PloS one, 2015 - journals.plos.org
Epidemiological studies enable us to analyze disease behavior, define risk factors and
establish fundamental prognostic criteria, with the purpose of studying different types of …

Breed‐predispositions to cancer in pedigree dogs

JM Dobson - International Scholarly Research Notices, 2013 - Wiley Online Library
Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs
may be affected, it is notable that some breeds of pedigree dogs appear to be at increased …

[HTML][HTML] Current biomarkers of canine mammary tumors

I Kaszak, A Ruszczak, S Kanafa, K Kacprzak… - Acta veterinaria …, 2018 - Springer
Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity
of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of …

Canine mammary tumours, an overview.

N Sleeckx, H De Rooster, VK EJ… - … in domestic animals …, 2011 - europepmc.org
Canine mammary tumours (CMTs) are the most common neoplasms in intact female dogs.
Although the prevalence of these tumours decreases in regions where preventive ovari …

[HTML][HTML] Naturally-occurring canine mammary tumors as a translational model for human breast cancer

M Gray, J Meehan, C Martínez-Pérez, C Kay… - Frontiers in …, 2020 - frontiersin.org
Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …

Dogs as a model for cancer

HL Gardner, JM Fenger… - Annual review of animal …, 2016 - annualreviews.org
Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

[HTML][HTML] Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs

K Wu, L Rodrigues, G Post, G Harvey, M White… - NPJ Precision …, 2023 - nature.com
Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

Breed variations in the incidence of pyometra and mammary tumours in Swedish dogs

S Jitpean, R Hagman, B Ström Holst… - … in domestic animals, 2012 - Wiley Online Library
Contents Dogs enrolled in a Swedish insurance company (during 1995–2006) were studied
for development of pyometra and mammary tumours (MT s), with special attention to breed …