Extensive growth in the field of molecular biology in recent decades has led to the
development of new and powerful experimental and computational tools that enable the …

The framework analysis previously presented for using DNA adduct information in the risk
assessment of chemical carcinogens was applied in a series of case studies which place the …

Assessing the potential carcinogenicity of chemicals for humans represents an ongoing
challenge. Chronic rodent bioassays predict human cancer risk at only limited reliability and …

Assessing the potential carcinogenicity of human toxins represents an ongoing challenge.
Chronic rodent bioassays predict human cancer risk with limited reliability, and are …

Purpose To identify the upstream regulators (URs) involved in the onset and pathogenesis
of ovarian endometrioma. Methods Recently, a method called Significance-based Modules …

Exposure to polycyclic aromatic hydrocarbons (PAHs) often occurs as complex chemical
mixtures, which are linked to numerous adverse health outcomes in humans, with cancer as …

Predictions of toxicity are central for the assessment of chemical toxicity, and the effects of
environmental toxic compounds are still a major issue for predicting potential human health …

Gene expression signatures of toxicity and clinical response benefit both safety assessment
and clinical practice; however, difficulties in connecting signature genes with the predicted …

Copper, though toxic in excess, is an essential trace element that serves as a cofactor in
many critical biological processes such as respiration, iron transport, and oxidative stress …

Well-established in vitro methods for testing the genotoxic potency of chemicals—such as
the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the …