Abstract Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical
degradation in the harsh environment of mucosal surfaces and enzymes of host or microbial …

The diversity and dynamics of the microbial species populating the human vagina are
increasingly understood to play a pivotal role in vaginal health. However, our knowledge …

Antiretroviral-releasing vaginal rings are at the forefront of ongoing efforts to develop
microbicide-based strategies for prevention of heterosexual transmission of the human …

We designed and engineered novel intravaginal ring (IVR) medical devices via fused
deposition modeling (FDM) three-dimensional (3D) printing for controlled delivery of …

Despite successful use, needle-based immunizations have several issues such as the risk of
injuries and infections from the reuse of needles and syringes and the low patient …

Mucosal immune responses are crucial in protecting against pathogens entering through
mucosal surfaces. However, due to poor T-cell responsiveness upon mucosal antigenic …

Drug-releasing vaginal rings are torus-shaped devices, generally fabricated from
thermoplastic polymers or silicone elastomers, used to administer pharmaceutical drugs to …

Optimal protective immunity to HIV will likely require that plasma cells, memory B cells and
memory T cells be stationed in mucosal tissues at portals of viral entry. Mucosal vaccine …

Recent estimates suggest that one in two sexually active individuals will acquire a sexually
transmitted infection by age 25, an alarming statistic that amounts to over 1 million new …

Human immunodeficiency virus (HIV) infection continues to pose a major infectious disease
threat worldwide. It is characterized by the depletion of CD4+ T cells, persistent immune …