Fundamentals of hdx-ms
V Vinciauskaite, GR Masson - Essays in Biochemistry, 2023 - portlandpress.com
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is becoming part of the
standard repertoire of techniques used by molecular biologists to investigate protein …
standard repertoire of techniques used by molecular biologists to investigate protein …
VWF, platelets and the antiphospholipid syndrome
S Huang, M Ninivaggi, W Chayoua… - International journal of …, 2021 - mdpi.com
The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy
morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Laboratory …
morbidity with the persistent presence of antiphospholipid antibodies (aPLs). Laboratory …
Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …
Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion
G Javitt, N Yeshaya, L Khmelnitsky… - Blood, The Journal of …, 2022 - ashpublications.org
The von Willebrand factor (VWF) glycoprotein is stored in tubular form in Weibel-Palade
bodies (WPBs) before secretion from endothelial cells into the bloodstream. The …
bodies (WPBs) before secretion from endothelial cells into the bloodstream. The …
[HTML][HTML] Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance
SE Ward, JM O'Sullivan, AB Moran… - …, 2021 - pmc.ncbi.nlm.nih.gov
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for
macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has …
macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has …
The biological significance of von Willebrand factor O-linked glycosylation
S Ward, JM O'Sullivan… - Seminars in Thrombosis …, 2021 - thieme-connect.com
Glycosylation is a key posttranslational modification, known to occur on more than half of all
secreted proteins in man. As such, the role of N-and O-linked glycan structures in …
secreted proteins in man. As such, the role of N-and O-linked glycan structures in …
Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module
Activation of von Willebrand factor (VWF) is a tightly controlled process governed primarily
by local elements around its A1 domain. Recent studies suggest that the O-glycosylated …
by local elements around its A1 domain. Recent studies suggest that the O-glycosylated …
The N-terminal autoinhibitory module of the A1 domain in von Willebrand factor stabilizes the mechanosensor catch bond
The von Willebrand factor (VWF), by interacting with the circulatory system and platelets,
harnesses hemodynamic forces to form hemostatic plugs or occlusive thrombi. The …
harnesses hemodynamic forces to form hemostatic plugs or occlusive thrombi. The …
[HTML][HTML] Desialylation of O‐glycans activates von Willebrand factor by destabilizing its autoinhibitory module
Background The binding of the A1 domain of von Willebrand factor (VWF) to platelet
receptor glycoprotein (GP) Ibα defines the VWF activity in hemostasis. Recent studies …
receptor glycoprotein (GP) Ibα defines the VWF activity in hemostasis. Recent studies …
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O-glycosylated N-and C-linker
Hemostasis in the arterial circulation is mediated by binding of the A1 domain of the
ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug …
ultralong protein von Willebrand factor (VWF) to GPIbα on platelets to form a platelet plug …