Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
TGF-β1–a truly transforming growth factor in fibrosis and immunity
Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …
Regulation of the immune response by TGF-β: from conception to autoimmunity and infection
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
Immunoregulation by members of the TGFβ superfamily
WJ Chen, P Ten Dijke - Nature Reviews Immunology, 2016 - nature.com
The transforming growth factor-β (TGFβ) superfamily is encoded by 33 genes and includes
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …
TGFβ, bone morphogenetic proteins (BMPs) and activins. Although TGFβ is well recognized …
TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis
T Sun, Z Huang, WC Liang, J Yin, WY Lin… - Science translational …, 2021 - science.org
Transforming growth factor–β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
(TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions in embryonic development; …
Aberrant T cell signaling and subsets in systemic lupus erythematosus
T Katsuyama, GC Tsokos, VR Moulton - Frontiers in immunology, 2018 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …
disease, which mainly afflicts women in the reproductive years. A complex interaction of …
TGF-β signaling in Th17 cells promotes IL-22 production and colitis-associated colon cancer
IL-22 has dual functions during tumorigenesis. Short term IL-22 production protects against
genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight …
genotoxic stress, whereas uncontrolled IL-22 activity promotes tumor growth; therefore, tight …
TGF-β: guardian of T cell function
SA Oh, MO Li - The Journal of Immunology, 2013 - journals.aai.org
A fundamental aspect of the adaptive immune system is the generation and maintenance of
a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development …
a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development …
Transforming growth factor-β signaling in regulatory T cells controls T helper-17 cells and tissue-specific immune responses
Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue
environments and against many inflammatory insults, yet the tissue-enriched factor (s) that …
environments and against many inflammatory insults, yet the tissue-enriched factor (s) that …
Cytokines in type 1 diabetes: mechanisms of action and immunotherapeutic targets
J Lu, J Liu, L Li, Y Lan, Y Liang - Clinical & translational …, 2020 - Wiley Online Library
Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …