Recent progress in targeted delivery vectors based on biomimetic nanoparticles

L Chen, W Hong, W Ren, T Xu, Z Qian… - Signal transduction and …, 2021 - nature.com
Over the past decades, great interest has been given to biomimetic nanoparticles (BNPs)
since the rise of targeted drug delivery systems and biomimetic nanotechnology. Biological …

[HTML][HTML] Novel approaches for vaccine development

MS Gebre, LA Brito, LH Tostanoski, DK Edwards… - Cell, 2021 - cell.com
Vaccines are critical tools for maintaining global health. Traditional vaccine technologies
have been used across a wide range of bacterial and viral pathogens, yet there are a …

Pre-clinical and clinical implications of “inside-out” vs.“outside-in” paradigms in multiple sclerosis etiopathogenesis

HE Titus, Y Chen, JR Podojil, AP Robinson… - Frontiers in cellular …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …

Immunogenicity of immunomodulatory, antibody-based, oncology therapeutics

J Davda, P Declerck, S Hu-Lieskovan… - … for immunotherapy of …, 2019 - Springer
The increasing use of multiple immunomodulatory (IMD) agents for cancer therapies (eg
antibodies targeting immune checkpoints, bispecific antibodies, and chimeric antigen …

Recent advances of nanotechnology application in autoimmune diseases–A bibliometric analysis

R He, L Li, T Zhang, X Ding, Y Xing, S Zhu, Z Gu, H Hu - Nano Today, 2023 - Elsevier
Autoimmune diseases are a group of serious immune system disorders that are usually
idiopathic and persistent. Currently, autoimmune diseases are often diagnosed after obvious …

Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice

G Casella, J Rasouli, A Boehm, W Zhang… - Science translational …, 2020 - science.org
Autoimmune diseases such as multiple sclerosis (MS) develop because of failed peripheral
immune tolerance for a specific self-antigen (Ag). Numerous approaches for Ag-specific …

Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental …

L Lu, S Qi, Y Chen, H Luo, S Huang, X Yu, Q Luo… - Biomaterials, 2020 - Elsevier
It is difficult to carry out early diagnosis and treatment of Multiple sclerosis (MS) because of
the complex pathogenesis elicited by diversified autoantigens. Monocytes play important …

A predictive mechanistic model of drug release from surface eroding polymeric nanoparticles

RT Stiepel, ES Pena, SA Ehrenzeller… - Journal of controlled …, 2022 - Elsevier
Effective drug delivery requires ample dosing at the target tissue while minimizing negative
side effects. Drug delivery vehicles such as polymeric nanoparticles (NPs) are often …

Nanoparticle-based drug delivery systems for induction of tolerance and treatment of autoimmune diseases

H Li, YG Yang, T Sun - Frontiers in bioengineering and biotechnology, 2022 - frontiersin.org
Autoimmune disease is a chronic inflammatory disease caused by disorders of immune
regulation. Antigen-specific immunotherapy has the potential to inhibit the autoreactivity of …

Mechanistic contributions of Kupffer cells and liver sinusoidal endothelial cells in nanoparticle-induced antigen-specific immune tolerance

LM Casey, KR Hughes, MN Saunders, SD Miller… - Biomaterials, 2022 - Elsevier
The intravenous delivery of disease-relevant antigens (Ag) by polymeric nanoparticles (NP-
Ags) has demonstrated Ag-specific immune tolerance in autoimmune and allergic disorders …