Blood brain barrier permeability prediction using machine learning techniques: an update
Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of
permeability that allow a limited range of drug and compounds to pass through it. The BBB …
permeability that allow a limited range of drug and compounds to pass through it. The BBB …
DeePred-BBB: A blood brain barrier permeability prediction model with improved accuracy
The blood-brain barrier (BBB) is a selective and semipermeable boundary that maintains
homeostasis inside the central nervous system (CNS). The BBB permeability of compounds …
homeostasis inside the central nervous system (CNS). The BBB permeability of compounds …
A machine learning-based quantitative model (LogBB_Pred) to predict the blood–brain barrier permeability (logBB value) of drug compounds
Motivation Efficient assessment of the blood–brain barrier (BBB) penetration ability of a drug
compound is one of the major hurdles in central nervous system drug discovery since …
compound is one of the major hurdles in central nervous system drug discovery since …
Prediction of the blood–brain barrier (BBB) permeability of chemicals based on machine-learning and ensemble methods
The ability of chemicals to enter the blood–brain barrier (BBB) is a key factor for central
nervous system (CNS) drug development. Although many models for BBB permeability …
nervous system (CNS) drug development. Although many models for BBB permeability …
[HTML][HTML] A recurrent neural network model to predict blood–brain barrier permeability
The rapid development of computational methods and the increasing volume of chemical
and biological data have contributed to an immense growth in chemical research. This field …
and biological data have contributed to an immense growth in chemical research. This field …
Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma
I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …
Explaining blood–brain barrier permeability of small molecules by integrated analysis of different transport mechanisms
FMG Cornelissen, G Markert, G Deutsch… - Journal of Medicinal …, 2023 - ACS Publications
The blood–brain barrier (BBB) represents a major obstacle to delivering drugs to the central
nervous system (CNS), resulting in the lack of effective treatment for many CNS diseases …
nervous system (CNS), resulting in the lack of effective treatment for many CNS diseases …
DeepBBBP: high accuracy blood‐brain‐barrier permeability prediction with a mixed deep learning model
Blood‐brain‐barrier permeability (BBBP) is an important property that is used to establish
the drug‐likeness of a molecule, as it establishes whether the molecule can cross the BBB …
the drug‐likeness of a molecule, as it establishes whether the molecule can cross the BBB …
Development of QSAR models to predict blood-brain barrier permeability
Assessing drug permeability across the blood-brain barrier (BBB) is important when
evaluating the abuse potential of new pharmaceuticals as well as developing novel …
evaluating the abuse potential of new pharmaceuticals as well as developing novel …
A classification model for blood brain barrier penetration
M Singh, R Divakaran, LSK Konda, R Kristam - Journal of Molecular …, 2020 - Elsevier
Traditional experimental approaches to evaluate the Blood-Brain Barrier (BBB) permeability
of a drug are expensive and time consuming. Hence, several computational models have …
of a drug are expensive and time consuming. Hence, several computational models have …