ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

About 40% of the eukaryotic cell's proteins are inserted co-or post-translationally in the
endoplasmic reticulum (ER), where they attain the native structure under the assistance of …

Conserved catabolic pathways operate to remove aberrant polypeptides from the
endoplasmic reticulum (ER), the major biosynthetic organelle of eukaryotic cells. The best …

Chronic saturated fatty acid exposure causes β-cell apoptosis and, thus, contributes to type
2 diabetes. Although endoplasmic reticulum (ER) stress and reduced ER-to-Golgi protein …

The endoplasmic reticulum (ER) is the biggest organelle in most cell types, but its
characterization as an organelle with a continuous membrane belies the fact that the ER is …

Human prion diseases are a group of rare neurodegenerative disorders characterized by
the conversion of the constitutively expressed prion protein, PrP C, into an abnormally …

Misfolded and abnormal β-sheets forms of wild-type proteins, such as cellular prion protein
(PrPC) and amyloid beta (Aβ), are believed to be the vectors of neurodegenerative …

Prion diseases are fatal neurodegenerative disorders caused by aberrant metabolism of the
cellular prion protein (PrPC). In genetic forms of these diseases, mutations in the globular C …

Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of
proteins attached to the extracellular leaflet of the plasma membrane via a post-translational …