Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

Acute kidney injury (AKI) is an increasing health burden with high morbidity and mortality
rates worldwide. AKI is a risk factor for chronic kidney disease (CKD) development and …

The crosstalk among the complement system, immune cells, and mediators of inflammation
provides an efficient mechanism to protect the organism against infections and support the …

Fibrosis is the common end point of chronic kidney disease. The persistent production of
inflammatory cytokines and growth factors leads to an ongoing process of extracellular …

microRNAs (miRNAs) are small, non-coding nucleotides that regulate diverse biological
processes. Altered microRNA biosynthesis or regulation contributes to pathological …

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and
atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ …

Tubulointerstitial injury is one of the hallmarks of renal disease. In particular, interstitial
fibrosis has a prominent role in the development and progression of kidney injury. Collagen …

Acute kidney injury (AKI) is an important health problem, affecting 13.3 million
individuals/year. It is associated with increased mortality, mainly in low-and middle-income …