Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …

Coagulation and the immune system interact in several physiological and pathological
conditions, including tissue repair, host defense, and homeostatic maintenance. This …

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …

Microglia, besides being able to react rapidly to a wide range of environmental changes, are
also involved in shaping neuronal wiring. Indeed, they actively participate in the modulation …

The animal model experimental autoimmune encephalomyelitis (EAE) has been used
extensively in the past to test mechanisms that target peripheral immune cells for treatment …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system
characterized by myelin loss and neuronal dysfunction. Although the majority of patients do …

Myelin-sensitive MRI such as magnetization transfer imaging has been widely used in
multiple sclerosis. The influence of methodology and differences in disease subtype on …

Multiple sclerosis is a heterogeneous disease with an unpredictable course and a wide
range of severity; some individuals rapidly progress to a disabled state whereas others …

MECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple
sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are …

Animal models of multiple sclerosis (MS) have been extensively used to characterize the
disease mechanisms in MS, as well as to identify potential pharmacologic targets for this …