Dementia prevention, intervention, and care

G Livingston, A Sommerlad, V Orgeta, SG Costafreda… - The lancet, 2017 - thelancet.com
Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

Spiking neural networks and online learning: An overview and perspectives

JL Lobo, J Del Ser, A Bifet, N Kasabov - Neural Networks, 2020 - Elsevier
Applications that generate huge amounts of data in the form of fast streams are becoming
increasingly prevalent, being therefore necessary to learn in an online manner. These …

Person‐specific contribution of neuropathologies to cognitive loss in old age

PA Boyle, L Yu, RS Wilson, SE Leurgans… - Annals of …, 2018 - Wiley Online Library
Objective Mixed neuropathologies are the most common cause of dementia at the
population level, but how different neuropathologies contribute to cognitive decline at the …

Type 2 diabetes, cognition, and dementia in older adults: toward a precision health approach

B Cholerton, LD Baker, TJ Montine… - Diabetes Spectrum, 2016 - Am Diabetes Assoc
IN BRIEF There has been a concurrent dramatic rise in type 2 diabetes and dementia in the
United States, and type 2 diabetes shares common genetic and environmental risk factors …

Precision medicine for disease modification in Parkinson disease

AJ Espay, P Brundin, AE Lang - Nature reviews neurology, 2017 - nature.com
In this Perspectives article, Espay and colleagues argue that that the adoption of precision
medicine in Parkinson disease will require a revision of biomarker development efforts, with …

Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease

Z Huang, GE Merrihew, EB Larson, J Park… - Nature …, 2023 - nature.com
Resilience to Alzheimer's disease is an uncommon combination of high disease burden
without dementia that offers valuable insights into limiting clinical impact. Here we assessed …

[HTML][HTML] Precision medicine-the golden gate for detection, treatment and prevention of Alzheimer's disease

H Hampel, SE O'Bryant, JI Castrillo… - The journal of …, 2016 - ncbi.nlm.nih.gov
During this decade, breakthrough conceptual shifts have commenced to emerge in the field
of Alzheimer's disease (AD) recognizing risk factors and the non-linear dynamic continuum …

Genetic data and cognitively defined late-onset Alzheimer's disease subgroups

S Mukherjee, J Mez, EH Trittschuh, AJ Saykin… - Molecular …, 2020 - nature.com
Categorizing people with late-onset Alzheimer's disease into biologically coherent
subgroups is important for personalized medicine. We evaluated data from five studies (total …

Cognitive impairment in older adults and therapeutic strategies

TJ Montine, SA Bukhari, LR White, V Hook - Pharmacological Reviews, 2021 - Elsevier
Cognitive impairment and its severe form dementia are increasingly prevalent in older adults
and loom as a public health disaster unless effective interventions are developed. Cognitive …

The role of genetics in advancing precision medicine for Alzheimer's disease—a narrative review

Y Freudenberg-Hua, W Li, P Davies - Frontiers in medicine, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia, which has a substantial
genetic component. AD affects predominantly older people. Accordingly, the prevalence of …