Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Background Pharmacogenomic testing guided treatment have been developed to guide
drug selection or conversion in major depressive disorder patients. Whether patients benefit …

Importance Selecting effective antidepressants for the treatment of major depressive
disorder (MDD) is an imprecise practice, with remission rates of about 30% at the initial …

Abstract 3D-printed tablets are a promising new approach for personalized medicine. In this
study, we fabricated composite tablets consisting of two components, a drug and a filler, by …

Many genetic variants in drug metabolizing enzymes and transporters have been shown to
be relevant for treating psychiatric disorders. Associations are strong enough to feature on …

The major human cytochrome P450 CYP2D6 isoform enzyme plays important roles in the
liver and in the brain with regards to xenobiotic metabolism. Xenobiotics as CYP2D6 …

Objectives: More than 40 drugs are available to treat affective disorders. Individual selection
of the optimal drug and dose is required to attain the highest possible efficacy and …

Antidepressant response could be from 42 to 50% genetically determined. Venlafaxine
(VEN) was the sixth most-prescribed antidepressant in the USA in 2017. Therefore, we …

Individuals carrying genetic variants that result in non-extensive CYP2D6 and CYP2C19
enzyme activity seem to be more prone to non-response and side-effects of psychotropic …

Cytochrome P450 2D6 (CYP2D6) is primarily expressed in the liver and in the central
nervous system. It is known to be highly polymorphic in nature. It metabolizes several …